InnateDB Protein
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IDBP-380274.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DCTN4
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Protein Name
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dynactin 4 (p62)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000411251
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InnateDB Gene
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IDBG-53953 (DCTN4)
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Protein Structure
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Function |
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:10671518}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:10671518}. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0047485
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protein N-terminus binding
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Biological Process |
GO:0019886
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antigen processing and presentation of exogenous peptide antigen via MHC class II
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Cellular Component |
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PDB ID |
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InterPro |
IPR008603
Dynactin p62
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PFAM |
PF05502
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UJW0
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PhosphoSite |
PhosphoSite-Q9UJW0
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TrEMBL |
Q9NSJ5
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UniProt Splice Variant |
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Entrez Gene |
51164
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UniGene |
Hs.675564
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RefSeq |
NP_001129116
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HUGO |
HGNC:15518
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OMIM |
614758
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CCDS |
CCDS47311
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HPRD |
13126
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IMGT |
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EMBL |
AC008450
AC008453
AF195120
AK000299
AK125973
AL162085
BC026323
CH471062
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GenPept |
AAF03896
AAH26323
BAA91066
BAG54272
CAB82417
EAW61706
EAW61707
EAW61709
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