InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE2A

Summary

InnateDB Protein

IDBP-380404.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE2A

Protein Name

phosphodiesterase 2A, cGMP-stimulated

Synonyms

CGS-PDE; cGSPDE; PDE2A1; PED2A4;

Species

Homo sapiens

Ensembl Protein

ENSP00000411657

InnateDB Gene

IDBG-63467 (PDE2A)

Protein Structure

UniProt Annotation

Function

Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration.

Subcellular Localization

Isoform PDE2A3: Cell membrane {ECO:0000269PubMed:19632989}; Lipid-anchor {ECO:0000269PubMed:19632989}.Isoform PDE2A2: Mitochondrion matrix {ECO:0000269PubMed:21724846}.Isoform PDE2A1: Cytoplasm {ECO:0000269PubMed:19632989}.Isoform 5: Mitochondrion {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0030552	cAMP binding
GO:0030553	cGMP binding
GO:0030911	TPR domain binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006198	cAMP catabolic process
GO:0006626	protein targeting to mitochondrion
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0019933	cAMP-mediated signaling
GO:0019934	cGMP-mediated signaling
GO:0030224	monocyte differentiation
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0033159	negative regulation of protein import into nucleus, translocation
GO:0035690	cellular response to drug
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0043116	negative regulation of vascular permeability
GO:0043117	positive regulation of vascular permeability
GO:0046069	cGMP catabolic process
GO:0050729	positive regulation of inflammatory response
GO:0061028	establishment of endothelial barrier
GO:0070588	calcium ion transmembrane transport
GO:0071260	cellular response to mechanical stimulus
GO:0071321	cellular response to cGMP
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005759	mitochondrial matrix
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0042734	presynaptic membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003018 GAF domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase
IPR029016 GAF domain-like

PFAM

PF00233
PF01590
PF13185
PF13492

PRINTS

PR00387

PIRSF

SMART

SM00065
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt