Version 5.4
Homo sapiens Gene: PDE2A
Summary
InnateDB Gene IDBG-63467.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE2A
Gene Name phosphodiesterase 2A, cGMP-stimulated
Synonyms CGS-PDE; cGSPDE; PDE2A1; PED2A4
Species Homo sapiens
Ensembl Gene ENSG00000186642
Encoded Proteins
IDBP-63469
phosphodiesterase 2A, cGMP-stimulated
IDBP-63471
phosphodiesterase 2A, cGMP-stimulated
IDBP-380404
phosphodiesterase 2A, cGMP-stimulated
IDBP-380406
phosphodiesterase 2A, cGMP-stimulated
IDBP-380407
phosphodiesterase 2A, cGMP-stimulated
IDBP-380410
phosphodiesterase 2A, cGMP-stimulated
IDBP-591031
phosphodiesterase 2A, cGMP-stimulated
IDBP-584528
phosphodiesterase 2A, cGMP-stimulated
IDBP-595615
phosphodiesterase 2A, cGMP-stimulated
IDBP-588549
phosphodiesterase 2A, cGMP-stimulated
IDBP-602791
phosphodiesterase 2A, cGMP-stimulated
IDBP-603798
phosphodiesterase 2A, cGMP-stimulated
IDBP-584098
phosphodiesterase 2A, cGMP-stimulated
IDBP-586229
phosphodiesterase 2A, cGMP-stimulated
IDBP-603272
phosphodiesterase 2A, cGMP-stimulated
IDBP-590374
phosphodiesterase 2A, cGMP-stimulated
IDBP-597680
phosphodiesterase 2A, cGMP-stimulated
IDBP-585419
phosphodiesterase 2A, cGMP-stimulated
IDBP-586598
phosphodiesterase 2A, cGMP-stimulated
IDBP-587115
phosphodiesterase 2A, cGMP-stimulated
IDBP-591895
phosphodiesterase 2A, cGMP-stimulated
IDBP-590386
phosphodiesterase 2A, cGMP-stimulated
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:72576141-72674591
Strand Reverse strand
Band q13.4
Transcripts
ENST00000334456 ENSP00000334910
ENST00000376450 ENSP00000365633
ENST00000444035 ENSP00000411657
ENST00000418754 ENSP00000410310
ENST00000420501 ENSP00000388997
ENST00000441209 ENSP00000392457
ENST00000475807 ENSP00000439077
ENST00000490749
ENST00000485058
ENST00000539367 ENSP00000445443
ENST00000544570 ENSP00000442256
ENST00000540345 ENSP00000446399
ENST00000536918
ENST00000544239
ENST00000542223 ENSP00000440834
ENST00000538299 ENSP00000441322
ENST00000536308 ENSP00000438559
ENST00000543750 ENSP00000438008
ENST00000543575 ENSP00000442797
ENST00000541998 ENSP00000438868
ENST00000538749 ENSP00000439683
ENST00000537631 ENSP00000443737
ENST00000540380
ENST00000535701 ENSP00000439302
ENST00000542969 ENSP00000443232
ENST00000546038 ENSP00000438295
ENST00000536458 ENSP00000445750
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004112 cyclic-nucleotide phosphodiesterase activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0030552 cAMP binding
GO:0030553 cGMP binding
GO:0030911 TPR domain binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006198 cAMP catabolic process
GO:0006626 protein targeting to mitochondrion
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0008152 metabolic process
GO:0019933 cAMP-mediated signaling
GO:0019934 cGMP-mediated signaling
GO:0030224 monocyte differentiation
GO:0030818 negative regulation of cAMP biosynthetic process
GO:0033159 negative regulation of protein import into nucleus, translocation
GO:0035690 cellular response to drug
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0043116 negative regulation of vascular permeability
GO:0043117 positive regulation of vascular permeability
GO:0046069 cGMP catabolic process
GO:0050729 positive regulation of inflammatory response
GO:0061028 establishment of endothelial barrier
GO:0070588 calcium ion transmembrane transport
GO:0071260 cellular response to mechanical stimulus
GO:0071321 cellular response to cGMP
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0042734 presynaptic membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030653
View Gene Order
ENSBTAG00000008419
Not yet available
Pathways
NETPATH
REACTOME
REACT_23767
cGMP effects pathway
REACT_23862
Nitric oxide stimulates guanylate cyclase pathway
REACT_23876
Platelet homeostasis pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_604
Hemostasis pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F5H2R8
UniProt Splice Variant
Entrez Gene 5138
UniGene Hs.503163
RefSeq NM_001143839 NM_001146209 NM_001243784 NM_002599 XM_005274040
HUGO HGNC:8777
OMIM 602658
CCDS CCDS44670 CCDS53678 CCDS73345 CCDS8216
HPRD 04041
IMGT
EMBL AP003065 AP005019
GenPept
RNA Seq Atlas 5138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca