InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLF12

Summary

InnateDB Protein

IDBP-38052.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLF12

Protein Name

Kruppel-like factor 12

Synonyms

AP-2rep; AP2REP;

Species

Homo sapiens

Ensembl Protein

ENSP00000366897

InnateDB Gene

IDBG-38048 (KLF12)

Protein Structure

UniProt Annotation

Function

Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0045944	positive regulation of transcription from RNA polymerase II promoter