Version 5.4
Homo sapiens Gene: KLF12
Summary
InnateDB Gene IDBG-38048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLF12
Gene Name Kruppel-like factor 12
Synonyms AP-2rep; AP2REP
Species Homo sapiens
Ensembl Gene ENSG00000118922
Encoded Proteins
IDBP-38052
Kruppel-like factor 12
IDBP-38056
Kruppel-like factor 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:73686089-74133905
Strand Reverse strand
Band q22.1
Transcripts
ENST00000377669 ENSP00000366897
ENST00000377666 ENSP00000366894
ENST00000472022
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000072294
View Gene Order
ENSBTAG00000044007
Not yet available
Cross-References
SwissProt Q9Y4X4
TrEMBL
UniProt Splice Variant
Entrez Gene 11278
UniGene Hs.373857
RefSeq NM_007249 XM_005266251 XM_005266252 XM_006719762
HUGO HGNC:6346
OMIM 607531
CCDS CCDS9449
HPRD
IMGT
EMBL AF113122 AF161471 AF312866 AF312867 AF312868 AF312869 AF312870 AF312871 AF312872 AJ243274 AK291397 AL138713 AL139036 AL159972 AL160032 BC019680 CH471093 HF546212
GenPept AAF14863 AAF29086 AAH19680 AAK12082 BAF84086 CAB46982 CAH70670 CAH71998 CAH74171 CAI15634 CCO02798 EAW80529
RNA Seq Atlas 11278

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca