InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCND2

Summary

InnateDB Protein

IDBP-38062.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCND2

Protein Name

potassium voltage-gated channel, Shal-related subfamily, member 2

Synonyms

KV4.2; RK5;

Species

Homo sapiens

Ensembl Protein

ENSP00000333496

InnateDB Gene

IDBG-38060 (KCND2)

Protein Structure

UniProt Annotation

Function

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. {ECO:0000269PubMed:10551270, ECO:0000269PubMed:10729221}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11102480}; Multi-pass membrane protein {ECO:0000269PubMed:11102480}. Cell projection, dendrite {ECO:0000269PubMed:11102480}. Note=Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression.

Disease Associations

Tissue Specificity

Highly expressed throughout the brain. Expression is very low or absent in other tissues. {ECO:0000269PubMed:10551270, ECO:0000269PubMed:10729221}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005250	A-type (transient outward) potassium channel activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001508	action potential
GO:0006811	ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0043197	dendritic spine

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003974 Potassium channel, voltage dependent, Kv3
IPR003975 Potassium channel, voltage dependent, Kv4
IPR004055 Potassium channel, voltage dependent, Kv4.2
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain
IPR021645 Shal-type voltage-gated potassium channels
IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal

PFAM

PF02214
PF00520
PF07885
PF11601
PF11879

PRINTS

PR00169
PR01491
PR01498
PR01497
PR01517

PIRSF

SMART

SM00225

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt