InnateDB Protein
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IDBP-380822.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD79A
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Protein Name
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CD79a molecule, immunoglobulin-associated alpha
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Synonyms
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IGA; MB-1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000400605
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InnateDB Gene
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IDBG-53375 (CD79A)
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Protein Structure
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Function |
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells. {ECO:0000269PubMed:8617796, ECO:0000269PubMed:9057631}.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. {ECO:0000250}.
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Disease Associations |
Agammaglobulinemia 3, autosomal recessive (AGM3) [MIM:613501]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269PubMed:10525050, ECO:0000269PubMed:11920841}. Note=The disease is caused by mutations affecting the gene represented in this entry. Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein.
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Tissue Specificity |
B-cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004888
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transmembrane signaling receptor activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003110
Phosphorylated immunoreceptor signalling ITAM
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PFAM |
PF02189
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PRINTS |
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PIRSF |
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SMART |
SM00077
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TIGRFAMs |
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Modification |
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SwissProt |
P11912
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PhosphoSite |
PhosphoSite-P11912
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
973
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UniGene |
Hs.631567
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RefSeq |
NP_067612
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HUGO |
HGNC:1698
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OMIM |
112205
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CCDS |
CCDS46088
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HPRD |
00203
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IMGT |
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EMBL |
AK223371
M74721
M80462
M86921
S46706
S75217
S79248
U05259
X13451
X83540
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GenPept |
AAA20495
AAA59556
AAA59557
AAA60270
AAB20812
AAB23558
AAC60653
BAD97091
CAA31802
CAA58523
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