Version 5.4
Homo sapiens Gene: CD79A
Summary
InnateDB Gene IDBG-53375.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD79A
Gene Name CD79a molecule, immunoglobulin-associated alpha
Synonyms IGA; MB-1
Species Homo sapiens
Ensembl Gene ENSG00000105369
Encoded Proteins
IDBP-53377
CD79a molecule, immunoglobulin-associated alpha
IDBP-380822
CD79a molecule, immunoglobulin-associated alpha
IDBP-764723
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:41877120-41881372
Strand Forward strand
Band q13.2
Transcripts
ENST00000221972 ENSP00000221972
ENST00000444740 ENSP00000400605
ENST00000597454 ENSP00000468922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 15 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0030183 B cell differentiation
GO:0042100 B cell proliferation
GO:0042113 B cell activation
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005771 multivesicular body
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019815 B cell receptor complex
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003379
View Gene Order
ENSBTAG00000001882
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
KEGG
hsa04662
B cell receptor signaling pathway pathway
hsa05340
Primary immunodeficiency pathway
INOH
INOH website
B cell receptor signaling pathway
PID NCI
bcr_5pathway
BCR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.631567
RefSeq NM_001783 NM_021601
HUGO
OMIM
CCDS CCDS12589 CCDS46088
HPRD 00203
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca