InnateDB Protein
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IDBP-380855.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UCP3
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Protein Name
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uncoupling protein 3 (mitochondrial, proton carrier)
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Synonyms
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SLC25A9;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000392143
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InnateDB Gene
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IDBG-64083 (UCP3)
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Protein Structure
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Function |
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269PubMed:9769326, ECO:0000269Ref.9}. Note=The gene represented in this entry may be involved in disease pathogenesis.
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Tissue Specificity |
Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles. {ECO:0000269PubMed:9196039}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002030
Mitochondrial brown fat uncoupling protein
IPR018108
Mitochondrial substrate/solute carrier
IPR023395
Mitochondrial carrier domain
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PFAM |
PF00153
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PRINTS |
PR00784
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P55916
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PhosphoSite |
PhosphoSite-P55916
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TrEMBL |
F5H3N5
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UniProt Splice Variant |
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Entrez Gene |
7352
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UniGene |
Hs.101337
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RefSeq |
NP_073714
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HUGO |
HGNC:12519
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OMIM |
602044
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CCDS |
CCDS44677
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HPRD |
03623
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IMGT |
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EMBL |
AF001787
AF011449
AF012197
AF012198
AF012199
AF012200
AF012201
AF012202
AF026956
AF026957
AF026958
AF050113
AP003717
BC008392
U82818
U84763
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GenPept |
AAC18822
AAC51356
AAC51367
AAC51369
AAC51767
AAC51785
AAG02284
AAH08392
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