Version 5.4
Homo sapiens Protein: P4HA3
Summary
InnateDB Protein IDBP-380963.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P4HA3
Protein Name prolyl 4-hydroxylase, alpha polypeptide III
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000401749
InnateDB Gene IDBG-64210 (P4HA3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004656 procollagen-proline 4-dioxygenase activity
GO:0005506 iron ion binding
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0019511 peptidyl-proline hydroxylation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID
InterPro IPR006620 Prolyl 4-hydroxylase, alpha subunit
IPR013547 Prolyl 4-hydroxylase alpha-subunit, N-terminal
PFAM PF08336
PRINTS
PIRSF
SMART SM00702
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z4N8
PhosphoSite PhosphoSite-Q7Z4N8
TrEMBL
UniProt Splice Variant
Entrez Gene 283208
UniGene Hs.733512
RefSeq NP_001275677
HUGO HGNC:30135
OMIM 608987
CCDS CCDS73347
HPRD 16413
IMGT
EMBL AK300598 AL833965 AP000577 AP001085 AY313448 AY327887 AY358521 BC089446 BC117333 BC126170 CH471076
GenPept AAH89446 AAI17334 AAI26171 AAP97874 AAQ87603 AAQ88885 BAG62295 CAI46215 EAW74935

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca