InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: P4HA3

Summary

InnateDB Gene

IDBG-64210.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4HA3

Gene Name

prolyl 4-hydroxylase, alpha polypeptide III

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000149380

Encoded Proteins

IDBP-64212

prolyl 4-hydroxylase, alpha polypeptide III

IDBP-380963

prolyl 4-hydroxylase, alpha polypeptide III

IDBP-602365

prolyl 4-hydroxylase, alpha polypeptide III

IDBP-584609

prolyl 4-hydroxylase, alpha polypeptide III

IDBP-599973

prolyl 4-hydroxylase, alpha polypeptide III

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:74235801-74311657

Strand

Reverse strand

Band

q13.4

Transcripts

ENST00000331597	ENSP00000332170
ENST00000427714	ENSP00000401749
ENST00000540363
ENST00000524388	ENSP00000433860
ENST00000532689	ENSP00000431350
ENST00000525968	ENSP00000431227
ENST00000531716

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004656	procollagen-proline 4-dioxygenase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0019511	peptidyl-proline hydroxylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000051048

View Gene Order

ENSBTAG00000006579

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00330

Arginine and proline metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.660541 Hs.662590 Hs.733512

RefSeq

NM_001288748 NM_182904 XM_005273924

HUGO

OMIM

CCDS

CCDS73347 CCDS8230

HPRD

16413

IMGT

EMBL

GenPept

RNA Seq Atlas