InnateDB Protein
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IDBP-381007.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SH2D3C
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Protein Name
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SH2 domain containing 3C
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Synonyms
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CHAT; NSP3; PRO34088; SHEP1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000394632
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InnateDB Gene
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IDBG-86372 (SH2D3C)
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Protein Structure
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Function |
Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with the membrane when EGF-stimulated. Found at ruffling membranes (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:10187783}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001895
Ras guanine-nucleotide exchange factors catalytic domain
IPR023578
Ras guanine nucleotide exchange factor domain
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PFAM |
PF00617
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PRINTS |
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PIRSF |
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SMART |
SM00147
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N5H7
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PhosphoSite |
PhosphoSite-Q8N5H7
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TrEMBL |
B3KUE2
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UniProt Splice Variant |
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Entrez Gene |
10044
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UniGene |
Hs.306412
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RefSeq |
NP_001136004
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HUGO |
HGNC:16884
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OMIM |
604722
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CCDS |
CCDS48028
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HPRD |
05284
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IMGT |
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EMBL |
AF124251
AK056068
AK096983
AK291393
AL162426
AL162586
AY358089
AY358440
BC027962
BC032365
BX647905
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GenPept |
AAD28246
AAH27962
AAH32365
AAQ88456
AAQ89948
BAF84082
BAG51614
BAG53404
CAI39761
CAI39763
CAI39766
CAI41177
CAI41179
CAI41182
CAI46101
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