Version 5.4
Homo sapiens Gene: SH2D3C
Summary
InnateDB Gene IDBG-86372.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH2D3C
Gene Name SH2 domain containing 3C
Synonyms CHAT; NSP3; PRO34088; SHEP1
Species Homo sapiens
Ensembl Gene ENSG00000095370
Encoded Proteins
IDBP-86374
SH2 domain containing 3C
IDBP-86376
SH2 domain containing 3C
IDBP-86378
SH2 domain containing 3C
IDBP-381007
SH2 domain containing 3C
IDBP-381009
SH2 domain containing 3C
IDBP-381010
SH2 domain containing 3C
IDBP-381012
SH2 domain containing 3C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:127738317-127778741
Strand Reverse strand
Band q34.11
Transcripts
ENST00000373277 ENSP00000362374
ENST00000314830 ENSP00000317817
ENST00000373276 ENSP00000362373
ENST00000429553 ENSP00000394632
ENST00000420366 ENSP00000388536
ENST00000440630 ENSP00000401641
ENST00000414380 ENSP00000413760
ENST00000468969
ENST00000484160
ENST00000471939
ENST00000464239
ENST00000488685
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 11 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0007254 JNK cascade
GO:0007264 small GTPase mediated signal transduction
GO:0009967 positive regulation of signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059013
View Gene Order
ENSBTAG00000015375
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.306412
RefSeq NM_001142531 NM_001142532 NM_001142533 NM_001142534 NM_001252334 NM_005489 NM_170600 XM_005251637 XM_005251639
HUGO
OMIM
CCDS CCDS48026 CCDS48028 CCDS59145 CCDS6877 CCDS6878
HPRD 05284
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca