InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DBF4

Summary

InnateDB Protein

IDBP-381032.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DBF4

Protein Name

DBF4 homolog (S. cerevisiae)

Synonyms

ASK; CHIF; DBF4A; ZDBF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000414083

InnateDB Gene

IDBG-25283 (DBF4)

Protein Structure

UniProt Annotation

Function

Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269PubMed:10373557, ECO:0000269PubMed:10523313, ECO:0000269PubMed:17062569}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10373557}.

Disease Associations

Tissue Specificity

Highly expressed in testis and thymus. Expressed also in most cancer cells lines. {ECO:0000269PubMed:10373557}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	24 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0008047	enzyme activator activity
GO:0008270	zinc ion binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0043085	positive regulation of catalytic activity