InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLXNB2

Summary

InnateDB Protein

IDBP-381041.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLXNB2

Protein Name

plexin B2

Synonyms

dJ402G11.3; MM1; Nbla00445; PLEXB2;

Species

Homo sapiens

Ensembl Protein

ENSP00000409171

InnateDB Gene

IDBG-13151 (PLXNB2)

Protein Structure

UniProt Annotation

Function

Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro) (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12533544}; Single-pass type I membrane protein {ECO:0000269PubMed:12533544}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017154	semaphorin receptor activity

Biological Process

GO:0001843	neural tube closure
GO:0001932	regulation of protein phosphorylation
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007405	neuroblast proliferation
GO:0007420	brain development
GO:0008360	regulation of cell shape
GO:0032319	regulation of Rho GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0050772	positive regulation of axonogenesis
GO:0071526	semaphorin-plexin signaling pathway
GO:2001222	regulation of neuron migration

Cellular Component

GO:0005622	intracellular
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001627 Sema domain
IPR002165 Plexin
IPR002909 IPT domain
IPR008936 Rho GTPase activation protein
IPR013548 Plexin, cytoplasmic RasGAP domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold

PFAM

PF01403
PF01437
PF01833
PF08337

PRINTS

PIRSF

SMART

SM00630
SM00429
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O15031