Version 5.4
Homo sapiens Gene: PLXNB2
Summary
InnateDB Gene IDBG-13151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLXNB2
Gene Name plexin B2
Synonyms dJ402G11.3; MM1; Nbla00445; PLEXB2
Species Homo sapiens
Ensembl Gene ENSG00000196576
Encoded Proteins
IDBP-13153
plexin B2
IDBP-381041
plexin B2
IDBP-381069
plexin B2
IDBP-381070
plexin B2
IDBP-381073
plexin B2
IDBP-381077
plexin B2
IDBP-381081
plexin B2
IDBP-808783
plexin B2
IDBP-808790
plexin B2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:50274979-50307627
Strand Reverse strand
Band q13.33
Transcripts
ENST00000359337 ENSP00000352288
ENST00000449103 ENSP00000409171
ENST00000411680 ENSP00000400679
ENST00000427829 ENSP00000406048
ENST00000434732 ENSP00000415757
ENST00000432455 ENSP00000392620
ENST00000425954 ENSP00000387470
ENST00000479701
ENST00000479818
ENST00000463165
ENST00000492578
ENST00000496720
ENST00000614805 ENSP00000478347
ENST00000610984 ENSP00000482999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017154 semaphorin receptor activity
Biological Process
GO:0001843 neural tube closure
GO:0001932 regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007405 neuroblast proliferation
GO:0007420 brain development
GO:0008360 regulation of cell shape
GO:0032319 regulation of Rho GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0050772 positive regulation of axonogenesis
GO:0071526 semaphorin-plexin signaling pathway
GO:2001222 regulation of neuron migration
Cellular Component
GO:0005622 intracellular
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036606
View Gene Order
ENSBTAG00000014966
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.3989
RefSeq NM_012401 XM_005261908 XM_005261909 XM_005261910 XM_005261911 XM_006724413
HUGO
OMIM
CCDS CCDS43035
HPRD 05050
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca