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InnateDB Protein
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IDBP-381111.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZGPAT
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Protein Name
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zinc finger, CCCH-type with G patch domain
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000403966
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InnateDB Gene
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IDBG-87143 (ZGPAT)
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Protein Structure
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| Function |
Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. {ECO:0000269PubMed:19644445}.Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. {ECO:0000269PubMed:19644445}.
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| Subcellular Localization |
Nucleus {ECO:0000269PubMed:19644445}.Isoform 4: Nucleus {ECO:0000269PubMed:20233718}.
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| Disease Associations |
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| Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:19644445}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
18
[view]
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| Protein-Protein |
18
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q8N5A5
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| TrEMBL |
X6RGY1
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| UniProt Splice Variant |
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| Entrez Gene |
84619
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| UniGene |
Hs.590868
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| RefSeq |
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| HUGO |
HGNC:15948
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| OMIM |
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| CCDS |
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| HPRD |
15736
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| IMGT |
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| EMBL |
AL121845
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| GenPept |
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Version 5.4