InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GABRG2

Summary

InnateDB Protein

IDBP-381124.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABRG2

Protein Name

gamma-aminobutyric acid (GABA) A receptor, gamma 2

Synonyms

CAE2; ECA2; GEFSP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000410732

InnateDB Gene

IDBG-56451 (GABRG2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004890	GABA-A receptor activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0008503	benzodiazepine receptor activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007268	synaptic transmission
GO:0009791	post-embryonic development
GO:0030534	adult behavior
GO:0034220	ion transmembrane transport
GO:0051932	synaptic transmission, GABAergic
GO:0055085	transmembrane transport
GO:0071420	cellular response to histamine
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0032590	dendrite membrane
GO:0034707	chloride channel complex
GO:0045211	postsynaptic membrane
GO:0060077	inhibitory synapse
GO:1902711	GABA-A receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
IPR005437 Gamma-aminobutyric-acid A receptor, gamma subunit
IPR005439 Gamma-aminobutyric-acid A receptor, gamma 2 subunit
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR01079
PR01620
PR01622
PR00253
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P18507