Version 5.4
Homo sapiens Protein: SFTPA2
Summary
InnateDB Protein IDBP-381182.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SFTPA2
Protein Name surfactant protein A2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000397375
InnateDB Gene IDBG-80070 (SFTPA2)
Protein Structure
UniProt Annotation
Function In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
Subcellular Localization Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
Disease Associations Pulmonary fibrosis, idiopathic (IPF) [MIM:178500]: A lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. In some cases, the disorder can be rapidly progressive and characterized by sequential acute lung injury with subsequent scarring and end-stage lung disease. {ECO:0000269PubMed:19100526}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 6 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR008160 Collagen triple helix repeat
PFAM PF01391
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q8IWL1
TrEMBL X6REF7
UniProt Splice Variant
Entrez Gene 729238
UniGene Hs.523084
RefSeq
HUGO HGNC:10799
OMIM 178642
CCDS
HPRD
IMGT
EMBL BX248123
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca