Version 5.4
Homo sapiens Gene: SFTPA2
Summary
InnateDB Gene IDBG-80070.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SFTPA2
Gene Name surfactant protein A2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000185303
Encoded Proteins
IDBP-80072
surfactant protein A2
IDBP-80074
surfactant protein A2
IDBP-381182
surfactant protein A2
IDBP-810691
surfactant protein A2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20413160
SFTPA2 is a carbohydrate pattern recognition molecule of innate immunity, that significantly enhances phagocytosis and killing of Aspergillus fumigatus, a pathogenic fungus, by neutrophils and macrophages.
Entrez Gene
Summary This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:79555852-79560397
Strand Reverse strand
Band q22.3
Transcripts
ENST00000372327 ENSP00000361402
ENST00000372325 ENSP00000361400
ENST00000417041 ENSP00000397375
ENST00000492049 ENSP00000473275
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 6 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0007585 respiratory gaseous exchange
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_23916
Signal regulatory protein (SIRP) family interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_6900
Immune System pathway
KEGG
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.523084
RefSeq NM_001098668 XM_005270128 XM_005270129 XM_005270131 XM_005270132
HUGO
OMIM
CCDS CCDS41540
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca