InnateDB Protein
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IDBP-381237.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HSBP1
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Protein Name
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heat shock factor binding protein 1
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Synonyms
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NPC-A-13;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000392896
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InnateDB Gene
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IDBG-306658 (HSBP1)
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Protein Structure
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|
Function |
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
|
Protein-Protein |
10
[view]
|
Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
1 [view]
|
|
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Molecular Function |
Accession |
GO Term |
GO:0003714
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transcription corepressor activity
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006936
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muscle contraction
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Cellular Component |
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PDB ID |
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InterPro |
IPR009643
Heat shock factor binding 1
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PFAM |
PF06825
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75506
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PhosphoSite |
PhosphoSite-O75506
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3281
|
UniGene |
Hs.741221
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RefSeq |
NP_001528
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HUGO |
HGNC:5203
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OMIM |
604553
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CCDS |
CCDS45534
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HPRD |
05185
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IMGT |
|
EMBL |
AF068754
AY320409
BC007515
BX537440
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GenPept |
AAC25186
AAH07515
AAP73809
CAD97682
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