Version 5.4
Homo sapiens Gene: HSBP1
Summary
InnateDB Gene IDBG-306658.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSBP1
Gene Name heat shock factor binding protein 1
Synonyms NPC-A-13
Species Homo sapiens
Ensembl Gene ENSG00000230989
Encoded Proteins
IDBP-381237
heat shock factor binding protein 1
IDBP-754081
IDBP-745985
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:83807843-83819737
Strand Forward strand
Band q23.3
Transcripts
ENST00000433866 ENSP00000392896
ENST00000570259 ENSP00000458007
ENST00000567382 ENSP00000456049
ENST00000569301
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006936 muscle contraction
Cellular Component
GO:0005634 nucleus
GO:0005856 cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031839
View Gene Order
ENSBTAG00000024889
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_200624
Attenuation phase pathway
REACT_200775
HSF1-dependent transactivation pathway
REACT_200819
Cellular response to heat stress pathway
REACT_200744
HSF1 activation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O75506
TrEMBL
UniProt Splice Variant
Entrez Gene 3281
UniGene Hs.250899 Hs.741221
RefSeq NM_001537
HUGO HGNC:5203
OMIM 604553
CCDS CCDS45534
HPRD 05185
IMGT
EMBL AF068754 AY320409 BC007515 BX537440
GenPept AAC25186 AAH07515 AAP73809 CAD97682
RNA Seq Atlas 3281

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca