InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC7A11

Summary

InnateDB Protein

IDBP-38127.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC7A11

Protein Name

solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

Synonyms

CCBR1; xCT;

Species

Homo sapiens

Ensembl Protein

ENSP00000280612

InnateDB Gene

IDBG-38125 (SLC7A11)

Protein Structure

UniProt Annotation

Function

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. {ECO:0000269PubMed:15151999}.

Subcellular Localization

Membrane {ECO:0000269PubMed:15151999}; Multi-pass membrane protein {ECO:0000269PubMed:15151999}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015171	amino acid transmembrane transporter activity
GO:0015327	cystine:glutamate antiporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006810	transport
GO:0006811	ion transport
GO:0006865	amino acid transport
GO:0006979	response to oxidative stress
GO:0007420	brain development
GO:0007596	blood coagulation
GO:0009636	response to toxic substance
GO:0015813	L-glutamate transport
GO:0035094	response to nicotine
GO:0050900	leukocyte migration
GO:0055085	transmembrane transport
GO:0070306	lens fiber cell differentiation
GO:0070527	platelet aggregation

Cellular Component

GO:0005791	rough endoplasmic reticulum
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR002293 Amino acid/polyamine transporter I
IPR004760 L-type amino acid transporter
IPR004841 Amino acid permease/ SLC12A domain
IPR013057 Amino acid transporter, transmembrane

PFAM

PF13520
PF00324
PF01490

PRINTS

PIRSF

PIRSF006060

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UPY5