InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC7A11

Summary

InnateDB Gene

IDBG-38125.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC7A11

Gene Name

solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

Synonyms

CCBR1; xCT

Species

Homo sapiens

Ensembl Gene

ENSG00000151012

Encoded Proteins

IDBP-38127

solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

IDBP-474731

solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:138164097-138242349

Strand

Reverse strand

Band

q28.3

Transcripts

ENST00000280612	ENSP00000280612
ENST00000509248	ENSP00000424046

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015171	amino acid transmembrane transporter activity
GO:0015327	cystine:glutamate antiporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006810	transport
GO:0006811	ion transport
GO:0006865	amino acid transport
GO:0006979	response to oxidative stress
GO:0007420	brain development
GO:0007596	blood coagulation
GO:0009636	response to toxic substance
GO:0015813	L-glutamate transport
GO:0035094	response to nicotine
GO:0050900	leukocyte migration
GO:0055085	transmembrane transport
GO:0070306	lens fiber cell differentiation
GO:0070527	platelet aggregation

Cellular Component

GO:0005791	rough endoplasmic reticulum
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027737

View Gene Order

ENSBTAG00000034075

Not yet available

Pathways

NETPATH

REACTOME

REACT_12560

Basigin interactions pathway

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_13796

Amino acid transport across the plasma membrane pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.390594 Hs.706054

RefSeq

NM_014331

HUGO

OMIM

CCDS

CCDS3742

HPRD

09720

IMGT

EMBL

GenPept

RNA Seq Atlas