Version 5.4
Homo sapiens Protein: EIF4E3
Summary
InnateDB Protein IDBP-381287.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4E3
Protein Name eukaryotic translation initiation factor 4E family member 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000410350
InnateDB Gene IDBG-44642 (EIF4E3)
Protein Structure
UniProt Annotation
Function Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005845 mRNA cap binding complex
Protein Structure and Domains
PDB ID
InterPro IPR001040 Translation Initiation factor eIF- 4e
IPR023398 Translation Initiation factor eIF- 4e-like domain
PFAM PF01652
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N5X7
PhosphoSite PhosphoSite-Q8N5X7
TrEMBL C9JUY2
UniProt Splice Variant
Entrez Gene 317649
UniGene Hs.714561
RefSeq NP_001128121
HUGO HGNC:31837
OMIM 609896
CCDS CCDS33786
HPRD 10687
IMGT
EMBL AC096970 AC097634 AC134770 AK126999 AK313656 BC031289 BC068443
GenPept AAH31289 AAH68443 BAG36410 BAG54418

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca