Version 5.4
Homo sapiens Gene: EIF4E3
Summary
InnateDB Gene IDBG-44642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4E3
Gene Name eukaryotic translation initiation factor 4E family member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163412
Encoded Proteins
IDBP-44644
eukaryotic translation initiation factor 4E family member 3
IDBP-44646
eukaryotic translation initiation factor 4E family member 3
IDBP-381286
eukaryotic translation initiation factor 4E family member 3
IDBP-381287
eukaryotic translation initiation factor 4E family member 3
IDBP-381289
eukaryotic translation initiation factor 4E family member 3
IDBP-480828
eukaryotic translation initiation factor 4E family member 3
IDBP-475131
eukaryotic translation initiation factor 4E family member 3
IDBP-475384
eukaryotic translation initiation factor 4E family member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:71675416-71754773
Strand Reverse strand
Band p13
Transcripts
ENST00000295612 ENSP00000295612
ENST00000389826 ENSP00000374476
ENST00000421769 ENSP00000411762
ENST00000448225 ENSP00000410350
ENST00000425534 ENSP00000393324
ENST00000481525
ENST00000468147
ENST00000497838 ENSP00000418211
ENST00000496214 ENSP00000417889
ENST00000469524 ENSP00000419421
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005845 mRNA cap binding complex
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
ENSBTAG00000018862
Not yet available
ENSMUSG00000093661
View Gene Order
Pathways
NETPATH
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.581355 Hs.603920 Hs.714561
RefSeq NM_001134649 NM_001134650 NM_001134651 NM_001282886 NM_173359
HUGO
OMIM
CCDS CCDS33786 CCDS46867
HPRD 10687
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca