Version 5.4
Homo sapiens Protein: NEDD1
Summary
InnateDB Protein IDBP-381440.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEDD1
Protein Name neural precursor cell expressed, developmentally down-regulated 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000407964
InnateDB Gene IDBG-52158 (NEDD1)
Protein Structure
UniProt Annotation
Function Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269PubMed:19029337, ECO:0000269PubMed:19509060}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:19029337}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
Experimentally validated
Total 69 [view]
Protein-Protein 66 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005813 centrosome
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NHV4
PhosphoSite PhosphoSite-Q8NHV4
TrEMBL G3V4I9
UniProt Splice Variant
Entrez Gene 121441
UniGene Hs.743848
RefSeq
HUGO HGNC:7723
OMIM 600372
CCDS CCDS44956
HPRD 02655
IMGT
EMBL AC007564 AC013417 AK093221 AK303656 AK315821 BC027605 CH471054
GenPept AAH27605 BAC04099 BAF98712 BAG64657 EAW97577 EAW97579 EAW97580

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca