InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE1B

Summary

InnateDB Protein

IDBP-38151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE1B

Protein Name

phosphodiesterase 1B, calmodulin-dependent

Synonyms

PDE1B1; PDES1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000243052

InnateDB Gene

IDBG-38149 (PDE1B)

Protein Structure

UniProt Annotation

Function

Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. {ECO:0000269PubMed:15260978}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516	calmodulin binding
GO:0046872	metal ion binding
GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0001505	regulation of neurotransmitter levels
GO:0001975	response to amphetamine
GO:0006198	cAMP catabolic process
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007596	blood coagulation
GO:0007626	locomotory behavior
GO:0008542	visual learning
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0030224	monocyte differentiation
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0042053	regulation of dopamine metabolic process
GO:0042428	serotonin metabolic process
GO:0045087	innate immune response
GO:0046069	cGMP catabolic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus

Cellular Component

GO:0005829	cytosol
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR013706 3\'5\'-cyclic nucleotide phosphodiesterase N-terminal
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233
PF08499

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt