InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDE1B

Summary

InnateDB Gene

IDBG-38149.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE1B

Gene Name

phosphodiesterase 1B, calmodulin-dependent

Synonyms

PDE1B1; PDES1B

Species

Homo sapiens

Ensembl Gene

ENSG00000123360

Encoded Proteins

IDBP-38151

phosphodiesterase 1B, calmodulin-dependent

IDBP-594489

phosphodiesterase 1B, calmodulin-dependent

IDBP-603213

phosphodiesterase 1B, calmodulin-dependent

IDBP-596754

phosphodiesterase 1B, calmodulin-dependent

IDBP-811351

phosphodiesterase 1B, calmodulin-dependent

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:54549350-54579239

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000243052	ENSP00000243052
ENST00000394277
ENST00000548855
ENST00000550285	ENSP00000447354
ENST00000538346	ENSP00000442559
ENST00000550620	ENSP00000448519
ENST00000542335
ENST00000552774
ENST00000611899	ENSP00000478185

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516	calmodulin binding
GO:0046872	metal ion binding
GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0001505	regulation of neurotransmitter levels
GO:0001975	response to amphetamine
GO:0006198	cAMP catabolic process
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007596	blood coagulation
GO:0007626	locomotory behavior
GO:0008542	visual learning
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0030224	monocyte differentiation
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0042053	regulation of dopamine metabolic process
GO:0042428	serotonin metabolic process
GO:0045087	innate immune response
GO:0046069	cGMP catabolic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus