InnateDB Protein
|
IDBP-381780.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ABCC3
|
Protein Name
|
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
|
Synonyms
|
ABC31; cMOAT2; EST90757; MLP2; MOAT-D; MRP3;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000395160
|
InnateDB Gene
|
IDBG-59146 (ABCC3)
|
Protein Structure
|
|
Function |
May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Membrane; Multi-pass membrane protein.
|
Disease Associations |
|
Tissue Specificity |
Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0005524
|
ATP binding
|
GO:0008514
|
organic anion transmembrane transporter activity
|
GO:0042626
|
ATPase activity, coupled to transmembrane movement of substances
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001140
ABC transporter, transmembrane domain
IPR011527
ABC transporter type 1, transmembrane domain
|
PFAM |
PF00664
PF13748
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O15438
|
PhosphoSite |
PhosphoSite-O15438
|
TrEMBL |
Q2M3C9
|
UniProt Splice Variant |
|
Entrez Gene |
8714
|
UniGene |
Hs.685104
|
RefSeq |
NP_001137542
|
HUGO |
HGNC:54
|
OMIM |
604323
|
CCDS |
CCDS45739
|
HPRD |
06826
|
IMGT |
|
EMBL |
AB010887
AC004590
AC005921
AF009670
AF083552
AF085690
AF085691
AF085692
AF104943
AF154001
BC046126
BC104952
BC137347
BC137348
CH471109
U83659
Y17151
|
GenPept |
AAB71756
AAC34668
AAD01430
AAD02845
AAD02846
AAD02847
AAD04170
AAD38185
AAH46126
AAI04953
AAI37348
AAI37349
BAA28146
CAA76658
EAW94590
EAW94592
EAW94593
|
|
|