Version 5.4
| Homo sapiens Gene: ABCC3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-59146.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | ABCC3 | ||||||||||||||||||
| Gene Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | ||||||||||||||||||
| Synonyms | ABC31; cMOAT2; EST90757; MLP2; MOAT-D; MRP3 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000108846 | ||||||||||||||||||
| Encoded Proteins |
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 17:50634777-50692252 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q21.33 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
ABC-family proteins mediated transport pathway
Recycling of bile acids and salts pathway
Transmembrane transport of small molecules pathway
Metabolism of lipids and lipoproteins pathway
Bile acid and bile salt metabolism pathway
Metabolism pathway
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| KEGG |
ABC transporters pathway
Bile secretion pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.463421 Hs.685104 | ||||||||||||||||||
| RefSeq | NM_001144070 NM_003786 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS32681 CCDS45739 | ||||||||||||||||||
| HPRD | 06826 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||