InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDK6

Summary

InnateDB Protein

IDBP-381850.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK6

Protein Name

cyclin-dependent kinase 6

Synonyms

PLSTIRE;

Species

Homo sapiens

Ensembl Protein

ENSP00000397087

InnateDB Gene

IDBG-26773 (CDK6)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. {ECO:0000269PubMed:12833137, ECO:0000269PubMed:14985467, ECO:0000269PubMed:15254224, ECO:0000269PubMed:15809340, ECO:0000269PubMed:17420273, ECO:0000269PubMed:17431401, ECO:0000269PubMed:20333249, ECO:0000269PubMed:20668294, ECO:0000269PubMed:8114739}.

Subcellular Localization

Cytoplasm. Nucleus. Cell projection, ruffle. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus.

Disease Associations

Tissue Specificity

Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells. {ECO:0000269PubMed:20668294, ECO:0000269PubMed:8114739}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	135 [view]
Protein-Protein	127 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030332	cyclin binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001954	positive regulation of cell-matrix adhesion
GO:0003323	type B pancreatic cell development
GO:0006468	protein phosphorylation
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0009615	response to virus
GO:0010468	regulation of gene expression
GO:0014002	astrocyte development
GO:0021542	dentate gyrus development
GO:0021670	lateral ventricle development
GO:0042063	gliogenesis
GO:0043697	cell dedifferentiation
GO:0045087	innate immune response (InnateDB)
GO:0045596	negative regulation of cell differentiation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045646	regulation of erythrocyte differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045786	negative regulation of cell cycle
GO:0048146	positive regulation of fibroblast proliferation
GO:0048699	generation of neurons
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051301	cell division
GO:2000145	regulation of cell motility
GO:2000773	negative regulation of cellular senescence

Cellular Component

GO:0000307	cyclin-dependent protein kinase holoenzyme complex
GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt