InnateDB Protein
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IDBP-381853.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FGF13
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Protein Name
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fibroblast growth factor 13
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Synonyms
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FGF-13; FGF2; FHF-2; FHF2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000409276
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InnateDB Gene
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IDBG-87799 (FGF13)
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Protein Structure
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Function |
Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. {ECO:0000269PubMed:15282281}.May regulate voltage-gated sodium channels transport and function. {ECO:0000269PubMed:15282281}.May also play a role in MAPK signaling. {ECO:0000269PubMed:15282281}.
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Subcellular Localization |
Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Nucleus {ECO:0000269PubMed:10644718}. Cytoplasm {ECO:0000269PubMed:10644718}. Note=Not secreted. {ECO:0000250}.Isoform 1: Nucleus, nucleolus.Isoform 2: Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Predominantly expressed in the nervous system. {ECO:0000269PubMed:9232594}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002209
Fibroblast growth factor family
IPR008996
Cytokine, IL-1-like
IPR028142
IL-1 family/FGF family
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PFAM |
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PRINTS |
PR00263
PR00262
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PIRSF |
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SMART |
SM00442
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TIGRFAMs |
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Modification |
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SwissProt |
Q92913
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PhosphoSite |
PhosphoSite-Q92913
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TrEMBL |
D3DWH3
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UniProt Splice Variant |
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Entrez Gene |
2258
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UniGene |
Hs.6540
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RefSeq |
NP_001132974
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HUGO |
HGNC:3670
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OMIM |
300070
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CCDS |
CCDS55511
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HPRD |
02090
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IMGT |
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EMBL |
AF100143
AF100144
AF199612
AF199613
AK297545
AK303685
AK316170
AL023798
AL023800
AL031386
AL034398
AL034416
AY672645
BC012347
BC034340
CH471150
U66198
Z81007
Z82193
Z82204
Z83313
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GenPept |
AAB18914
AAD16400
AAD16401
AAF31399
AAF31400
AAH12347
AAH34340
AAT70720
BAH12613
BAH14016
BAH14541
CAI42696
CAI95616
CAI95677
EAW88435
EAW88436
EAW88438
EAW88439
EAW88440
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