Version 5.4
Homo sapiens Gene: FGF13
Summary
InnateDB Gene IDBG-87799.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF13
Gene Name fibroblast growth factor 13
Synonyms FGF-13; FGF2; FHF-2; FHF2
Species Homo sapiens
Ensembl Gene ENSG00000129682
Encoded Proteins
IDBP-87803
fibroblast growth factor 13
IDBP-87805
fibroblast growth factor 13
IDBP-381853
fibroblast growth factor 13
IDBP-381855
fibroblast growth factor 13
IDBP-381856
fibroblast growth factor 13
IDBP-381857
fibroblast growth factor 13
IDBP-381860
fibroblast growth factor 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5\' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:138631574-139222777
Strand Reverse strand
Band q27.1
Transcripts
ENST00000305414 ENSP00000303391
ENST00000315930 ENSP00000322390
ENST00000441825 ENSP00000409276
ENST00000436198 ENSP00000396198
ENST00000455663 ENSP00000406916
ENST00000448673 ENSP00000411999
ENST00000421460 ENSP00000388688
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008083 growth factor activity
GO:0017080 sodium channel regulator activity
GO:0030295 protein kinase activator activity
GO:0044325 ion channel binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0000165 MAPK cascade
GO:0001764 neuron migration
GO:0007026 negative regulation of microtubule depolymerization
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007399 nervous system development
GO:0007612 learning
GO:0007613 memory
GO:0021766 hippocampus development
GO:0021795 cerebral cortex cell migration
GO:0045200 establishment of neuroblast polarity
GO:0045860 positive regulation of protein kinase activity
GO:0046785 microtubule polymerization
GO:0048671 negative regulation of collateral sprouting
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0014704 intercalated disc
GO:0030175 filopodium
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031137
View Gene Order
ENSBTAG00000020194
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
FGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt Q92913
TrEMBL
UniProt Splice Variant
Entrez Gene 2258
UniGene Hs.6540
RefSeq NM_001139498 NM_001139500 NM_001139501 NM_001139502 NM_004114 NM_033642 XM_005262399
HUGO HGNC:3670
OMIM 300070
CCDS CCDS14664 CCDS14665 CCDS55511
HPRD 02090
IMGT
EMBL AF100143 AF100144 AF199612 AF199613 AK297545 AK303685 AK316170 AL023798 AL023800 AL031386 AL034398 AL034416 AY672645 BC012347 BC034340 CH471150 U66198 Z81007 Z82193 Z82204 Z83313
GenPept AAB18914 AAD16400 AAD16401 AAF31399 AAF31400 AAH12347 AAH34340 AAT70720 BAH12613 BAH14016 BAH14541 CAI42696 CAI95616 CAI95677 EAW88435 EAW88438 EAW88440
RNA Seq Atlas 2258

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca