Version 5.4
Homo sapiens Protein: ISYNA1
Summary
InnateDB Protein IDBP-38187.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ISYNA1
Protein Name inositol-3-phosphate synthase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000337746
InnateDB Gene IDBG-38183 (ISYNA1)
Protein Structure
UniProt Annotation
Function Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds. {ECO:0000269PubMed:15024000}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in testis, ovary, heart, placenta and pancreas. Weakly expressed in blood leukocyte, thymus, skeletal muscle and colon. {ECO:0000269PubMed:12941308}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004512 inositol-3-phosphate synthase activity
Biological Process
GO:0006021 inositol biosynthetic process
GO:0008654 phospholipid biosynthetic process
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR002587 Myo-inositol-1-phosphate synthase
IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like
PFAM PF07994
PF01658
PRINTS
PIRSF PIRSF015578
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPH2
PhosphoSite PhosphoSite-Q9NPH2
TrEMBL J3QRY0
UniProt Splice Variant
Entrez Gene 51477
UniGene Hs.740475
RefSeq NP_057452
HUGO HGNC:29821
OMIM 611670
CCDS CCDS12379
HPRD 17163
IMGT
EMBL AC008397 AF086921 AF207640 AF220250 AF220251 AF220252 AF220253 AF220254 AF220255 AF220256 AF220257 AF220258 AF220259 AF220530 AK001325 AK021526 AK092179 AL137749 BC004320 BC018952 BC066902 CH471106
GenPept AAF26444 AAF26739 AAG35698 AAH04320 AAH18952 AAH66902 AAP97151 BAA91626 BAB13837 BAG52493 CAB70904 EAW84703 EAW84705 EAW84706

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca