Version 5.4
Homo sapiens Gene: ISYNA1
Summary
InnateDB Gene IDBG-38183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ISYNA1
Gene Name inositol-3-phosphate synthase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105655
Encoded Proteins
IDBP-38187
inositol-3-phosphate synthase 1
IDBP-375994
inositol-3-phosphate synthase 1
IDBP-762952
IDBP-761913
IDBP-764212
IDBP-766179
IDBP-806627
inositol-3-phosphate synthase 1
IDBP-763603
IDBP-761705
IDBP-765663
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:18434388-18438301
Strand Reverse strand
Band p13.11
Transcripts
ENST00000338128 ENSP00000337746
ENST00000457269 ENSP00000415458
ENST00000582287
ENST00000583309
ENST00000583816
ENST00000581672 ENSP00000464528
ENST00000577820 ENSP00000463271
ENST00000582770 ENSP00000464209
ENST00000577916
ENST00000582811 ENSP00000463628
ENST00000578963 ENSP00000475677
ENST00000578352 ENSP00000462001
ENST00000581800 ENSP00000463500
ENST00000583534 ENSP00000464430
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004512 inositol-3-phosphate synthase activity
Biological Process
GO:0006021 inositol biosynthetic process
GO:0008654 phospholipid biosynthetic process
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019139
View Gene Order
ENSBTAG00000017482
Not yet available
Pathways
NETPATH
REACTOME
REACT_150352
Synthesis of IP2, IP, and Ins in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.405873 Hs.740475
RefSeq NM_001170938 NM_001253389 NM_016368
HUGO
OMIM
CCDS CCDS12379 CCDS54234 CCDS62603
HPRD 17163
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca