InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOX4

Summary

InnateDB Protein

IDBP-382007.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOX4

Protein Name

NADPH oxidase 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000412446

InnateDB Gene

IDBG-67316 (NOX4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0009055	electron carrier activity
GO:0016174	NAD(P)H oxidase activity
GO:0016491	oxidoreductase activity
GO:0019826	oxygen sensor activity
GO:0020037	heme binding
GO:0050660	flavin adenine dinucleotide binding
GO:0072341	modified amino acid binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006954	inflammatory response
GO:0007569	cell aging
GO:0008285	negative regulation of cell proliferation
GO:0042554	superoxide anion generation
GO:0045087	innate immune response (InnateDB)
GO:0050667	homocysteine metabolic process
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005730	nucleolus
GO:0005789	endoplasmic reticulum membrane
GO:0005925	focal adhesion
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000778 Cytochrome b245, heavy chain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF08022
PF08030
PF01794

PRINTS

PR00466

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NPH5