Version 5.4
Homo sapiens Gene: NOX4
Summary
InnateDB Gene IDBG-67316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOX4
Gene Name NADPH oxidase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000086991
Encoded Proteins
IDBP-67318
NADPH oxidase 4
IDBP-67320
NADPH oxidase 4
IDBP-67322
NADPH oxidase 4
IDBP-243926
NADPH oxidase 4
IDBP-382007
NADPH oxidase 4
IDBP-586795
NADPH oxidase 4
IDBP-589631
NADPH oxidase 4
IDBP-584016
NADPH oxidase 4
IDBP-592407
NADPH oxidase 4
IDBP-592527
NADPH oxidase 4
IDBP-596721
NADPH oxidase 4
IDBP-595582
NADPH oxidase 4
IDBP-583446
NADPH oxidase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18511861
NOX4 is implicated in innate immunity since lipopolysaccharide (LPS) induces NOX4-dependent reactive oxygen species (ROS) generation.
Entrez Gene
Summary This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:89324356-89498187
Strand Reverse strand
Band q14.3
Transcripts
ENST00000263317 ENSP00000263317
ENST00000343727 ENSP00000344747
ENST00000375979 ENSP00000365146
ENST00000393282 ENSP00000376961
ENST00000424319 ENSP00000412446
ENST00000534731 ENSP00000436892
ENST00000525196 ENSP00000436716
ENST00000532825 ENSP00000434924
ENST00000527956 ENSP00000433797
ENST00000524473
ENST00000527626 ENSP00000436093
ENST00000528341 ENSP00000436970
ENST00000531342 ENSP00000435039
ENST00000529343 ENSP00000435474
ENST00000525278
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0016174 NAD(P)H oxidase activity
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0016491 oxidoreductase activity
GO:0019826 oxygen sensor activity
GO:0020037 heme binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050664 oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
GO:0072341 modified amino acid binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001666 response to hypoxia
GO:0006801 superoxide metabolic process
GO:0006954 inflammatory response
GO:0007568 aging
GO:0007569 cell aging
GO:0008285 negative regulation of cell proliferation
GO:0014911 positive regulation of smooth muscle cell migration
GO:0042554 superoxide anion generation
GO:0043065 positive regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045453 bone resorption
GO:0050667 homocysteine metabolic process
GO:0051496 positive regulation of stress fiber assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0055007 cardiac muscle cell differentiation
GO:0055114 oxidation-reduction process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0071333 cellular response to glucose stimulus
GO:0071480 cellular response to gamma radiation
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072593 reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000573 positive regulation of DNA biosynthetic process
Cellular Component
GO:0001725 stress fiber
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005925 focal adhesion
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0043020 NADPH oxidase complex
GO:0048471 perinuclear region of cytoplasm
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030562
View Gene Order
ENSBTAG00000018540
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ptp1bpathway
Signaling events mediated by PTP1B
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.371036 Hs.591995
RefSeq NM_001143836 NM_001143837 NM_001291926 NM_001291927 NM_001291929 NM_001300995 NM_016931 XM_006718849 XM_006718850 XM_006718851 XM_006718852
HUGO
OMIM
CCDS CCDS44695 CCDS44696 CCDS73361 CCDS73362 CCDS8285
HPRD 09243
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca