Version 5.4
Homo sapiens Protein: PARPBP
Summary
InnateDB Protein IDBP-382022.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARPBP
Protein Name chromosome 12 open reading frame 48
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000393867
InnateDB Gene IDBG-53547 (PARPBP)
Protein Structure
UniProt Annotation
Function Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect. {ECO:0000269PubMed:20931645, ECO:0000269PubMed:22153967}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269PubMed:20931645, ECO:0000269PubMed:22153967}. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA.
Disease Associations
Tissue Specificity Restricted to testis. Overexpressed in multiple cancer cells. {ECO:0000269PubMed:20931645}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:2000042 negative regulation of double-strand break repair via homologous recombination
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NWS1
PhosphoSite PhosphoSite-Q9NWS1
TrEMBL
UniProt Splice Variant
Entrez Gene 55010
UniGene Hs.330663
RefSeq
HUGO HGNC:26074
OMIM 613687
CCDS
HPRD 07937
IMGT
EMBL AC087882 AK000648 AK303571 BC018903 BC030962 BC050696 BC070270 BC098313 BC099734 BC099844
GenPept AAH18903 AAH30962 AAH50696 AAH70270 AAH98313 AAH99734 AAH99844 BAA91306 BAG64592

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca