InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AMOTL1

Summary

InnateDB Protein

IDBP-382267.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AMOTL1

Protein Name

angiomotin like 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387739

InnateDB Gene

IDBG-68376 (AMOTL1)

Protein Structure

UniProt Annotation

Function

Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269PubMed:22362771}.

Subcellular Localization

Cell junction, tight junction {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0003365	establishment of cell polarity involved in ameboidal cell migration
GO:0016055	Wnt signaling pathway
GO:0035329	hippo signaling
GO:0043536	positive regulation of blood vessel endothelial cell migration

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005923	tight junction
GO:0008180	COP9 signalosome
GO:0016324	apical plasma membrane
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0031410	cytoplasmic vesicle