Version 5.4
Homo sapiens Gene: AMOTL1
Summary
InnateDB Gene IDBG-68376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AMOTL1
Gene Name angiomotin like 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166025
Encoded Proteins
IDBP-68378
angiomotin like 1
IDBP-68380
angiomotin like 1
IDBP-382267
angiomotin like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:94706431-94876753
Strand Forward strand
Band q21
Transcripts
ENST00000317829 ENSP00000320968
ENST00000299004 ENSP00000299004
ENST00000433060 ENSP00000387739
ENST00000539727
ENST00000537191
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0003365 establishment of cell polarity involved in ameboidal cell migration
GO:0016055 Wnt signaling pathway
GO:0035329 hippo signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005923 tight junction
GO:0008180 COP9 signalosome
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013076
View Gene Order
ENSBTAG00000018945
Not yet available
Pathways
NETPATH
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.503594 Hs.594931
RefSeq NM_001301007 NM_130847 XM_005273798 XM_005273800 XM_005273801 XM_006718771
HUGO
OMIM
CCDS CCDS44712 CCDS73368
HPRD 12451
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca