InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMYD1

Summary

InnateDB Protein

IDBP-382285.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMYD1

Protein Name

SET and MYND domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000393453

InnateDB Gene

IDBG-60363 (SMYD1)

Protein Structure

UniProt Annotation

Function

Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expression seems mostly restricted to heart and skeletal muscle. {ECO:0000269PubMed:19783823}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0007507	heart development
GO:0010831	positive regulation of myotube differentiation
GO:0034968	histone lysine methylation
GO:0035914	skeletal muscle cell differentiation
GO:0045663	positive regulation of myoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated