Version 5.4
Homo sapiens Protein: PON2
Summary
InnateDB Protein IDBP-382293.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PON2
Protein Name paraoxonase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000405211
InnateDB Gene IDBG-27758 (PON2)
Protein Structure
UniProt Annotation
Function Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. {ECO:0000269PubMed:11579088, ECO:0000269PubMed:15772423}.
Subcellular Localization Membrane {ECO:0000269PubMed:11579088}; Peripheral membrane protein {ECO:0000269PubMed:11579088}.
Disease Associations
Tissue Specificity Widely expressed with highest expression in liver, lung, placenta, testis and heart. {ECO:0000269PubMed:11579088}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004064 arylesterase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0019439 aromatic compound catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15165
PhosphoSite PhosphoSite-Q15165
TrEMBL
UniProt Splice Variant
Entrez Gene 5445
UniGene Hs.735870
RefSeq
HUGO HGNC:9205
OMIM 602447
CCDS
HPRD 03903
IMGT
EMBL AB102891 AC005021 AF001601 AF001602 AF001603 AK291103 AK296029 AK315209 AY210982 BC040010 CH236949 L48513
GenPept AAC27944 AAC27945 AAC27946 AAC41995 AAC62431 AAH40010 AAO18083 BAD89420 BAF83792 BAG37646 BAG58797 EAL24131

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca