InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FNBP1

Summary

InnateDB Protein

IDBP-382344.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FNBP1

Protein Name

formin binding protein 1

Synonyms

FBP17;

Species

Homo sapiens

Ensembl Protein

ENSP00000413625

InnateDB Gene

IDBG-89354 (FNBP1)

Protein Structure

UniProt Annotation

Function

May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269PubMed:15252009, ECO:0000269PubMed:16318909, ECO:0000269PubMed:16326391, ECO:0000269PubMed:16418535, ECO:0000269PubMed:17512409}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.

Disease Associations

Note=A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with KMT2A/MLL1. The relatively low incidence of the KMT2A/MLL1-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.

Tissue Specificity

Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain. {ECO:0000269PubMed:11438682, ECO:0000269PubMed:15252009}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0042802	identical protein binding

Biological Process

GO:0006412	translation
GO:0006897	endocytosis
GO:0007165	signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005764	lysosome
GO:0005840	ribosome
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0005938	cell cortex
GO:0016023	cytoplasmic membrane-bounded vesicle