InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MGAT1

Summary

InnateDB Protein

IDBP-382768.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGAT1

Protein Name

mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Synonyms

GLCNAC-TI; GLCT1; GLYT1; GNT-1; GNT-I; MGAT;

Species

Homo sapiens

Ensembl Protein

ENSP00000402838

InnateDB Gene

IDBG-62498 (MGAT1)

Protein Structure

UniProt Annotation

Function

Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.

Subcellular Localization

Golgi apparatus membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Appears to be present in all tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
GO:0008375	acetylglucosaminyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006486	protein glycosylation
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process