Version 5.4
Homo sapiens Gene: MGAT1
Summary
InnateDB Gene IDBG-62498.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGAT1
Gene Name mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Synonyms GLCNAC-TI; GLCT1; GLYT1; GNT-1; GNT-I; MGAT
Species Homo sapiens
Ensembl Gene ENSG00000131446
Encoded Proteins
IDBP-62500
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-62502
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-243823
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-382767
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-382768
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-483783
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-479442
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-481542
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-479646
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-485277
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-481847
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-474627
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-481646
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
IDBP-476080
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:180790541-180815652
Strand Reverse strand
Band q35.3
Transcripts
ENST00000333055 ENSP00000332073
ENST00000307826 ENSP00000311888
ENST00000393340 ENSP00000377010
ENST00000446023 ENSP00000404718
ENST00000427865 ENSP00000402838
ENST00000504671 ENSP00000424891
ENST00000506889 ENSP00000425988
ENST00000514283 ENSP00000424382
ENST00000512695 ENSP00000427116
ENST00000506269 ENSP00000422906
ENST00000514438 ENSP00000421738
ENST00000502678 ENSP00000422588
ENST00000513431 ENSP00000423401
ENST00000507384 ENSP00000427433
ENST00000504385
ENST00000514760
ENST00000505682
ENST00000512080
ENST00000510341
ENST00000508702
ENST00000513149
ENST00000510962
ENST00000508090
ENST00000506708
ENST00000506033
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
GO:0008375 acetylglucosaminyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0005975 carbohydrate metabolic process
GO:0006049 UDP-N-acetylglucosamine catabolic process
GO:0006486 protein glycosylation
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020346
View Gene Order
ENSBTAG00000001546
Not yet available
Pathways
NETPATH
REACTOME
REACT_25210
N-glycan trimming and elongation in the cis-Golgi pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6R9U2 D6RA48 D6RAK2 D6RB69 D6RBS3 D6RD15 D6RF69 D6RHZ8 D6RIS2
UniProt Splice Variant
Entrez Gene 4245
UniGene Hs.519818
RefSeq NM_001114617 NM_001114618 NM_001114619 NM_001114620 NM_002406 XM_005265915 XM_005265916 XM_006714866 XM_006714867
HUGO HGNC:7044
OMIM 160995
CCDS CCDS4458
HPRD 01189
IMGT
EMBL AC022413
GenPept
RNA Seq Atlas 4245

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca