Version 5.4
Homo sapiens Protein: FOXN4
Summary
InnateDB Protein IDBP-382820.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXN4
Protein Name forkhead box N4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000408085
InnateDB Gene IDBG-56011 (FOXN4)
Protein Structure
UniProt Annotation
Function Transcription factor essential for neural and some non- neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4- NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00089}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001158 enhancer sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0001947 heart looping
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008016 regulation of heart contraction
GO:0010842 retina layer formation
GO:0035881 amacrine cell differentiation
GO:0036302 atrioventricular canal development
GO:0045893 positive regulation of transcription, DNA-templated
GO:0060579 ventral spinal cord interneuron fate commitment
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96NZ1
PhosphoSite PhosphoSite-Q96NZ1
TrEMBL
UniProt Splice Variant
Entrez Gene 121643
UniGene Hs.606827
RefSeq
HUGO HGNC:21399
OMIM 609429
CCDS
HPRD 13550
IMGT
EMBL AC012384 AF425596 AF425597 AK131519
GenPept AAL23949 AAL23950 BAD18661

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca