Version 5.4
Homo sapiens Gene: FOXN4
Summary
InnateDB Gene IDBG-56011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXN4
Gene Name forkhead box N4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139445
Encoded Proteins
IDBP-56013
forkhead box N4
IDBP-56015
forkhead box N4
IDBP-382820
forkhead box N4
IDBP-807015
forkhead box N4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:109277979-109309220
Strand Reverse strand
Band q24.11
Transcripts
ENST00000299162 ENSP00000299162
ENST00000355216 ENSP00000347354
ENST00000423960 ENSP00000408085
ENST00000468516 ENSP00000474754
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001158 enhancer sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001947 heart looping
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008016 regulation of heart contraction
GO:0010842 retina layer formation
GO:0030154 cell differentiation
GO:0035881 amacrine cell differentiation
GO:0036302 atrioventricular canal development
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048663 neuron fate commitment
GO:0060579 ventral spinal cord interneuron fate commitment
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042002
View Gene Order
ENSBTAG00000010847
Not yet available
Cross-References
SwissProt Q96NZ1
TrEMBL
UniProt Splice Variant
Entrez Gene 121643
UniGene Hs.528316 Hs.606827
RefSeq NM_213596
HUGO HGNC:21399
OMIM 609429
CCDS CCDS9126
HPRD 13550
IMGT
EMBL AC012384 AF425596 AF425597 AK131519
GenPept AAL23949 AAL23950 BAD18661
RNA Seq Atlas 121643

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca