InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FUT2

Summary

InnateDB Protein

IDBP-382831.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FUT2

Protein Name

fucosyltransferase 2 (secretor status included)

Synonyms

B12QTL1; SE; Se2; SEC2; sej;

Species

Homo sapiens

Ensembl Protein

ENSP00000387498

InnateDB Gene

IDBG-60943 (FUT2)

Protein Structure

UniProt Annotation

Function

Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.

Subcellular Localization

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Disease Associations

Tissue Specificity

Small intestine, colon and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity
GO:0008417	fucosyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006486	protein glycosylation
GO:0036065	fucosylation
GO:0042355	L-fucose catabolic process

Cellular Component

GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome