InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAPGEF1

Summary

InnateDB Protein

IDBP-382997.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAPGEF1

Protein Name

Rap guanine nucleotide exchange factor (GEF) 1

Synonyms

C3G; GRF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000407210

InnateDB Gene

IDBG-90109 (RAPGEF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622

intracellular

Protein Structure and Domains

PDB ID

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00618
PF00617

PRINTS

PIRSF

SMART

SM00229
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite